Osseointegration and soft tissue response to gradually anodized surface implants: Real-world data from a 1000-patient study including clinically compromised subpopulations.

Introduction

Enhancing osseointegration and promoting healthy soft tissue outcomes strive to expand the successful use of implant-based oral rehabilitations for patients with comorbidities and other challenging conditions. Optimizing the implant surface by gradual anodization from a moderately rough apex to the minimally rough collar employing various implant geometries endeavors to achieve this goal. 

Key Results

• Mean patient age was 53.2 ± 11.71 years (range 18-71) with females comprising 54.9% of the population. 
• Of the 1026 patients, 81 (7.9%) were nicotine users, 45 (4.4%) had parafunctional tendencies, 86 (8.4%) had a history of periodontitis, 16 (1.6%) of peri-implantitis, 18 (1.8%) of severe oral mucositis, 23 (2.2%) diabetes, and 61 (5.9%) other significant diseases including osteoporosis, took bisphosphonates, or had various cancers (but no oral cancer). 
• Simultaneous GBR was administered at 25.3% of implant sites. 
• Of the 1564 implants placed in 1002 treated patients, 35 failures occurred during the 0-42.8 months of follow-up.

Citation

Presented at  the 32nd Annual Scientific Meeting of the European Association for Osseointegration (EAO), September 18-20, 2025.

De Santis D, Roig Cayón M, Fabbri G, Staas T, Männistö V, Crosby T, Antoun H, Prinz W, Ferro A, de Araújo Nobre M, Sleiter R, Brunner F, Scherg S, Eshraghi T, Kowar J, Crooke E, Noharet R, Kold S, Kold L, Haas R, Guazzato M, Ghibaudo M, Avontroodt P, Raghoebar G, Mesquida J, Stillmann R, Carmichael G, Liddelow G  Osseointegration and soft tissue response to gradually anodized surface implants: Real-world data from a 1000-patient study including clinically compromised subpopulations. E-Poster EAO 2025 (P382) Clin Oral Impl Res; Vol 36 (S29): 131-132 DOI: 10.1111/clr.70007

References

Milleret V, Lienemann PS, Gasser A, Bauer S, Ehrbar M, Wennerberg A. Rational design and in vitro characterization of novel dental implant and abutment surfaces for balancing clinical and biological needs.  Clin Implant Dent Relat Res. 2019 Mar;21 Suppl 1:15-24 

Authors

Daniele de Santis, Miguel Roig Cayón, Giacomo Fabbri, Tristan Staas, Ville Männistö, Tricia Crosby, Hadi Antoun, Wolfgang Prinz, Ana Ferro, Miguel de Araújo Nobre, Roberto Sleiter, Flavio Brunner, Stefan Scherg, Thomas Eshraghi, Jan Kowar, Eduard Crooke, Renaud Noharet, Simon Kold, Louise Kold, Robert Haas, Massimiliano Guazzato, Matthieu Ghibaudo, Pieter Avontroodt, Gerry Raghoebar, Juan Mesquida, Robert Stillmann, Graham Carmichael, Glen Liddelow.